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KMID : 0811820070110010092
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Journal of Korean Society of Pediatric Nephrology
2007 Volume.11 No. 1 p.92 ~ p.99
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A Case of Posterior Reversible Encephalopathy Syndrome during Cyclosporine Therapy in a Child with Steroid Resistant Nephrotic Syndrome
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Jeong Min-Hee
Lee Joo-Hoon
Yum Mi-Sun
Ko Tae-Sung
Park Young-Seo
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Abstract
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The posterior reversible encephalopathy syndrome(PRES) is characterized clinically by a combination of acute or subacute confusion, lethargy, visual disturbance, and seizures. PRES has been described in various clinical settings, including severe hypertension, chemotherapy, eclampsia, and seizure. We report a case of a 7-year-old girl who had taken cyclosporine for steroid resistant nephrotic syndrome. Twenty one days after the cyclosporine therapy, she was admitted due to generalized tonic clonic seizure and headache. Her blood pressure was 170/90 mmHg. Magnetic resonance(MR) imaging showed necrotic/cystic lesions involving the bilateral parieto-occipital region. After discontinuation of cyclosporine, and control of blood pressure, she had no more seizure and headache. The follow-up MR examination which was performed 6 months later showed the decreased extent of the lesion.
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KEYWORD
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Steroid resistant nephrotic syndrome, Posterior reversible encephalopathy syndrome, Cyclosporine
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